The contact owns a 2016 Ford F-150. The contact stated that while the vehicle was parked, the vehicle failed to start. The contactas husband went underneath the vehicle to maneuver the gear shifter cable and the vehicle was able to start. While driving approximately 45 MPH, the vehicle lost motive power and started to decelerate. The contact coasted to the side of the road where the vehicle was turned off. After waiting and after several attempts the vehicle was restarted, and the contact continued driving. The failure had occurred several times intermittently. The contact stated that the gear indicator lights on the instrument panel failed to illuminate. The vehicle was taken to the dealer who diagnosed that the transmission had failed and needed to be replaced. The vehicle was not repaired. The manufacturer was informed of the failure. The manufacturer transferred the contact to the NHTSA Hotline to report the failure. The failure mileage was approximately 150,000.